| Identification | Back Directory | [Name]
1H-Indole-2-carboxamide, N-[4-amino-1-(2-chloroethyl)-2-naphthalenyl]-5,6,7-trimethoxy- | [CAS]
413577-16-9 | [Synonyms]
1H-Indole-2-carboxamide, N-[4-amino-1-(2-chloroethyl)-2-naphthalenyl]-5,6,7-trimethoxy- | [Molecular Formula]
C24H24ClN3O4 | [MOL File]
413577-16-9.mol | [Molecular Weight]
453.92 |
| Hazard Information | Back Directory | [Uses]
Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening[1]. | [Definition]
ChEBI: AS-I-145 is an indolecarboxamide obtained by the formal condensation of the carboxy group of 5,6,7-trimethoxyindole-2-carboxylic acid with the 2-amino group of 1-(2-chloroethyl)-2,4-diaminonaphthalene. It has a role as an antineoplastic agent. It is an indolecarboxamide, an aromatic amine, an aromatic ether and an organochlorine compound. | [References]
[1] Rayburn E, et al. Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent. Cancer Chemother Pharmacol. 2012;69(6):1423-1431. DOI:10.1007/s00280-012-1851-9 |
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