| Identification | Back Directory | [Name]
2,4-DIETHYLPYRIDINE DICARBOXYLATE | [CAS]
41438-38-4 | [Synonyms]
2,4-DPD
Ai3-17897
Diethyl-2,4-pdc
2,4-Pdc diethyl ester
2,4-Pyridinedicarboxylic
DIETHYL 2,4-PYRIDINECARBOXYLATE
Diethyl 2,4-pyridinedicarboxylate
2,4-DIETHYLPYRIDINE DICARBOXYLATE
diethyl pyridine-2,4-dicarboxylate
diethyl 2,4-pyridinedicarboxylic acid
2,4-DIETHYL PYRIDINE-2,4-DICARBOXYLATE
2,4-pyridinedicarboxylicacid,ethylester
2,4-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
pyridine-2,4-dicarboxylic acid diethyl ester
2,4-pyridine dicarboxylic acid 2,4-diethyl ester
2,4-Pyridinedicarboxylic acid, diethyl ester
Pyridine-2,4-Dicarboxylic Acid Diethyl Ester | [EINECS(EC#)]
680-341-5 | [Molecular Formula]
C11H13NO4 | [MDL Number]
MFCD00152168 | [MOL File]
41438-38-4.mol | [Molecular Weight]
223.23 |
| Chemical Properties | Back Directory | [Melting point ]
31 °C | [Boiling point ]
330.9±22.0 °C(Predicted) | [density ]
1.165±0.06 g/cm3(Predicted) | [vapor pressure ]
0.022Pa at 25℃ | [storage temp. ]
2-8°C | [solubility ]
≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide | [form ]
Crystalline | [pka]
-0.69±0.10(Predicted) | [color ]
White to Almost white | [LogP]
1.92 at 20℃ and pH7.82 | [Surface tension]
56.3mN/m at 1g/L and 19.7℃ | [CAS DataBase Reference]
41438-38-4 |
| Hazard Information | Back Directory | [Uses]
Diethyl pyridine-2,4-dicarb is a potent prolyl 4-hydroxylase-directed proinhibitor. Diethyl pyridine-2,4-dicarb inhibits prolyl hydroxylation and procollagen processing in chick-embryo calvaria[1]. | [Biological Activity]
2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1]. | [storage]
Store at -20°C | [References]
[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.
[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626. |
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