| Identification | Back Directory | [Name]
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- | [CAS]
415919-74-3 | [Synonyms]
GPR30 agonist-1
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- | [Molecular Formula]
C19H17BrFNO | [MOL File]
415919-74-3.mol | [Molecular Weight]
374.25 |
| Chemical Properties | Back Directory | [Boiling point ]
446.7±45.0 °C(Predicted) | [density ]
1.394±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 50 mg/mL (133.60 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
4.32±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1]. | [in vivo]
GPR30 agonist-1 (compound 5408-0877) (1 nM-10 μM) induces a concentration-dependent relaxation in carotid arteries from both male and female rats. GPR30 agonist-1-induced relaxation is abolished by endothelium removal and abrogated in the presence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (100 μM)[1]. | [References]
[1] Brad R S Broughton, et al. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1055-61. DOI:10.1152/ajpheart.00878.2009 |
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