| Identification | Back Directory | [Name]
CATHARANTHINE TARTRATE | [CAS]
4168-17-6 | [Synonyms]
CATHARANTHINE TARTRATE
Catharanthine hemitartrate
CATHARANTHINE TARTRATE USP/EP/BP
Bis[(5ξ,18ξ)-18-(methoxycarbonyl)-3,4-didehydroibogamin-6-ium] tartarate
(2α,5β,6α,18β)-3,4-Didehydro-ibogaMine-18-carboxylic Acid Methyl Ester Tartrate
(2alpha,5beta,6alpha,18beta)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester (2R,3R)-2,3-dihydroxybutanedioate
7-ETHYL-9,10,12,13-TETRAHYDRO-6,9-METHANO-5H-PYRIDO[1',2':1,2]AZEPINO[4,5-B]INDOLE-6(6AH)-CARBOXYLIC ACID METHYL ESTER TARTRATE | [Molecular Formula]
C25H30N2O8 | [MDL Number]
MFCD06410944 | [MOL File]
4168-17-6.mol | [Molecular Weight]
486.51 |
| Chemical Properties | Back Directory | [Melting point ]
145-1470C | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
White to off-white crystalline powder. | [color ]
White to Pale Beige | [InChIKey]
JYBKPXVXYJDIFX-GYMDHWDQSA-N | [SMILES]
[C@]12(C(OC)=O)[C@]3(C(=C[C@]([H])(CN3CCC3C4=C(C=CC=C4)NC1=3)C2)CC)[H].C(O)(C(O)=O)C(O)C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Beige Solid | [Uses]
Precursor of Vinblastine-type alkaloids. | [Biological Activity]
Starting material for the synthesis of the antitumor drugs vinblastine and vincristine. It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds. | [Synthesis]
Using fresh whole Catharanthus roseus plant:
1) Soaking in NaCl solution, freeze-drying, and pulverizing.
2) Acidic extraction, basification, and counter-current extraction using a spray method with an extractant (n-bromopropane/ethanol).
3) Work | [in vivo]
Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) Tartrate evokes dose-dependent reductions in both BP and HR[1].
Catharanthine (40 mg/kg; ip; single dose) Tartrate with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h[1].
Catharanthine (20 mg/kg; ip; for 14 consecutive days) Tartrate increases swimming time and decreases immobility time at D7 or D14 in mice[1].
| Animal Model: | 13-week-old male SpragueDawley rats (300-350 g)[1] | | Dosage: | 0.5-20 mg/kg | | Administration: | IV; single dose | | Result: | Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.
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| [IC 50]
L-type calcium channel |
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