| Identification | Back Directory | [Name]
sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate | [CAS]
41733-55-5 | [Synonyms]
Fursemide sodium
FuroseMide (sodiuM)
Sodium 5-(aminosulfonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid sodium salt | [EINECS(EC#)]
255-526-5 | [Molecular Formula]
C12H11ClN2NaO5S | [MDL Number]
MFCD23379919 | [MOL File]
41733-55-5.mol | [Molecular Weight]
353.734 |
| Hazard Information | Back Directory | [Uses]
Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl-?(NKCC) cotransporter, NKCC1 and NKCC2[1].?Furosemide sodium is also a GABAA?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2]. | [in vivo]
Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is injected after kanamycin (KM) (1000 mg/kg) to creat a deaf mouse model in C57BL/6 mouse. After injection, hearing loss and cochlear hair cell damage are evaluated on day 1, day 2 and day 3, respectively. The hearing is markedly deteriorated even from the next day (Day-1 group), OHCs (outer hair cell) morphology of apical, middle and basal turns are disorganized in mice on day3[1]. | [References]
[1] C M Gillen, et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J Biol Chem. 1996 Jul 5;271(27):16237-44. DOI:10.1074/jbc.271.27.16237
[2] S A Thompson, et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by Furosemide sodium. Mol Pharmacol. 1999 Jun;55(6):993-9. DOI:10.1124/mol.55.6.993
[3] Shin Hye Kim, et al. Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide sodium-Treated Mice. Front Cell Neurosci.?2018 Jan 19;12:3. DOI:10.3389/fncel.2018.00003
[4] Atsushi Shiozaki?, et al. Furosemide sodium, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state. J Physiol Sci.?2006 Dec;56(6):401-6. DOI:10.2170/physiolsci.RP010806
[5] Yuliya V Kucherenko, et al.Inhibitory effect of Furosemide sodium on non-selective voltage-independent cation channels in human erythrocytes.Cell Physiol Biochem. 2012;30(4):863-75. DOI:10.1159/000341464 |
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