| Identification | Back Directory | [Name]
2,3-DCPE HYDROCHLORIDE | [CAS]
418788-90-6 | [Synonyms]
2,3-DCPE
2,3-DCPEHCl
3-DCPE hydrochloride
2,3-DCPE HYDROCHLORIDE
2,3 DCPE hydrochloride,2,3DCPE hydrochloride
2-[3-(2,3-dichlorophenoxy)propylamino]ethanol
Ethanol, 2-[[3-(2,3-dichlorophenoxy)propyl]amino]-
2-[[3-(2,3-DICHLOROPHENOXY)PROPYL]AMINO]ETHANOL HYDROCHLORIDE | [Molecular Formula]
C11H15Cl2NO2 | [MDL Number]
MFCD01454883 | [MOL File]
418788-90-6.mol | [Molecular Weight]
264.15 |
| Chemical Properties | Back Directory | [Boiling point ]
402.9±40.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
20 mg/ml in DMSO | [form ]
Powder | [pka]
14.78±0.10(Predicted) | [Water Solubility ]
Soluble in water at ~25 mg/ml. Also soluble in ethanol, DMSO or DMF at ~20mg/ml. Soluble in PBS, pH 7.2 at ~10 mg/ml. |
| Hazard Information | Back Directory | [Uses]
2,3-DCPE induces apoptosis and downregulates Bcl-XL expression. 2,3-DCPE has anti-tumor activity and can be used in cancer research[1]. | [Biological Activity]
Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro . IC 50 values are 0.89 and 12.6 μ M for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. | [References]
[1] Wu S, et al. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 2004 Feb 1;64(3):1110-3. DOI:10.1158/0008-5472.can-03-2790 |
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