| Identification | Back Directory | [Name]
N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE | [CAS]
41927-06-4 | [Synonyms]
TOSLAB-BB TOS-BB-1282
2-(5,6-dimethyl-1H-benzimidazol-2-yl)guanidine
N-(5,6-DIMETHYL-1H-BENZIMIDAZOL-2-YL)GUANIDINE
Guanidine, (5,6-dimethyl-1H-benzimidazol-2-yl)- (9CI) | [Molecular Formula]
C10H13N5 | [MDL Number]
MFCD00087632 | [MOL File]
41927-06-4.mol | [Molecular Weight]
203.24 |
| Hazard Information | Back Directory | [Uses]
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM[1]. | [References]
[1] Francesconi V, et al., Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents. ACS Infect Dis. 2024 Jul 2. DOI:10.1021/acsinfecdis.4c00113 |
|
|