| Identification | Back Directory | [Name]
FOLINIC ACID CALCIUM SALT PENTAHYDRATE | [CAS]
41927-89-3 | [Synonyms]
LEUCOVORIN PENTAHYDRATE
CALCIUM FOLINATE PENTAHYDRATE
LEUCOVORIN CALCIUM SALT PENTAHYDRATE
FOLINIC ACID CALCIUM SALT PENTAHYDRATE
5-HCO-H4PTEGLU CALCIUM SALT PENTAHYDRATE
CITROVORUM FACTOR CALCIUM SALT PENTAHYDRATE
FOLINIC ACID CALCIUM SALT PENTAHYDRATE USP/EP/BP
5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT
5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT PENTAHYDRATE
5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE
N5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE | [Molecular Formula]
C20H31CaN7O12 | [MDL Number]
MFCD00149465 | [MOL File]
41927-89-3.mol | [Molecular Weight]
601.58 |
| Chemical Properties | Back Directory | [Melting point ]
240-250 °C | [storage temp. ]
0-6°C | [solubility ]
Aqueous (Slightly, Sonicated), Water (Sparingly, Heated, Sonicated) | [form ]
Solid | [color ]
Off-White to Pale Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Anti-anemic (folate deficiency); antidote (to folic acid
antagonists). | [Brand name]
Wellcovorin (GlaxoSmithKline). | [Clinical Use]
Folinic acid rescue
Enhancement of 5-fluorouracil cytotoxicity in
advanced colorectal cancer
Folate deficiency | [Drug interactions]
Potentially hazardous interactions with other drugs
Should not be administered simultaneously with a
folic acid antagonist as this may nullify the effect of
the antagonist.
Cytotoxics: avoid with panitumumab and raltitrexed. | [Metabolism]
Folinic acid is a racemate where the L-form (L-5-
formyl-tetrahydrofolate, L-5-formyl-THF), is the active
enantiomer. The major metabolic product of folinic acid
is 5-methyl-tetrahydrofolic acid (5-methyl-THF) which
is predominantly produced in the liver and intestinal
mucosa.
80-90% with the urine (5- and 10-formyltetrahydrofolates
inactive metabolites), 5-8% with the
faeces. |
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