| Identification | Back Directory | [Name]
1-hydroxyethyl-4-nitropyrazole | [CAS]
42027-81-6 | [Synonyms]
M and B 4998
2-(4-Nitro-1H-pyrazol-1-yl)
1-hydroxyethyl-4-nitropyrazole
1H-Pyrazole-1-ethanol, 4-nitro-
1beta-Hydroxyethyl-4-nitropyrazole
2-(4-nitro-1H-pyrazol-1-yl)ethan-1-ol
1-(2-Hydroxyethyl)-4-nitro-1H-pyrazole | [Molecular Formula]
C5H7N3O3 | [MOL File]
42027-81-6.mol | [Molecular Weight]
157.13 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: A mixture of 2-bromoethanol (3.75 g, 30.00 mmol), 4-nitropyrazole (3.39 g, 30.00 mmol) and potassium carbonate (K2CO3, 4.97 g, 36.00 mmol) in acetonitrile (30 mL) was heated and refluxed for 16 hours. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to remove the solvent to afford the crude product 1-(2-hydroxyethyl)-4-nitro-1H-pyrazole as a white solid (4.70 g, yield: 100%), which could be used in the next reaction without further purification. The product was analyzed by electrospray ionization mass spectrometry (ESI-MS) and showed a molecular ion peak (M + H)+ m/z of 158.0. | [References]
[1] Patent: WO2015/89337, 2015, A1. Location in patent: Paragraph 0214
[2] Patent: WO2009/154769, 2009, A1. Location in patent: Page/Page column 41
[3] Patent: WO2016/42341, 2016, A1. Location in patent: Page/Page column 183; 184
[4] Patent: WO2015/48281, 2015, A1. Location in patent: Paragraph 00413; 00414
[5] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0342; 0343 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Shanghai Uchem Inc.
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15618758386 15618758386 |
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https://www.chemicalbook.com/ShowSupplierProductsList15300/0_EN.htm |
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Rhawn Reagent
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400-400-1332688 18019345275 |
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http://www.rhawn.cn |
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