| Identification | Back Directory | [Name]
Samidorphan | [CAS]
421552-35-4 | [Synonyms]
Samidorphan
Samidorphan N-1
Morphinan-3-carboxamide, 17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-6-oxo-, (5α)- | [Molecular Formula]
C21H24N2O4 | [MOL File]
421552-35-4.mol | [Molecular Weight]
368.43 |
| Chemical Properties | Back Directory | [Boiling point ]
547.2±50.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [pka]
13.22±0.20(Predicted) | [InChIKey]
QAICPHMNUHNDMC-PIBUYISVNA-N | [SMILES]
O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])N(CC1CC1)CC[C@@]23C4=5)C(=O)N |&1:1,6,15,24,r| |
| Hazard Information | Back Directory | [Uses]
3-Carboxamidonaltrexone (example 32) is a opioid receptor binding compound with Ki values of 1.9 nM, 110 nM, and 22 nM for μ-opioid receptor, δ-opioid receptor, and K-opioid receptor, respectively[1]. | [IC 50]
μ Opioid Receptor/MOR: 1.9 nM (Ki); κ Opioid Receptor/KOR: 22 nM (Ki); δ Opioid Receptor/DOR: 110 nM (Ki) | [References]
[1] Mark P. Wentland. 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents. WO2002036573A2. |
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| Company Name: |
TOSUN PHARM Gold
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61855200 13326451905 |
| Website: |
www.toref.cn/ |
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