42417-39-0

1192-20-7

42417-39-0

General procedure for the synthesis of 3-amino dihydrofuran-2(3H)-one hydrochloride from 3-amino dihydrofuran-2(3H)-one: 100 ml of solvent was added to a single-necked flask, to which were added sequentially 2 g of 2-(hydroxy-imino)-γ-butyrolactone, wet 0.2 g of 10% palladium-carbon catalyst, 30 ml of solvent and 3 ml of glacial acetic acid. The reaction was carried out at 40°C for 4 hours under hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was filtered using diatomaceous earth and the palladium-carbon catalyst was recycled. The solvent was removed by distillation under reduced pressure to give a colorless transparent oil. To this oily substance 100 ml of saturated HCl/ethyl acetate solution was added, stirred for 0.5 h and then filtered and dried. The final product 3-amino dihydrofuran-2(3H)-one hydrochloride was obtained as 2.3 g in 96% yield.