| Identification | Back Directory | [Name]
POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT | [CAS]
42424-50-0 | [Synonyms]
Poly(I) •
Poly(I:C) sodium
POLY I POLY C, NA
Polymyocyte sodium salt
POLY[I] POLY[C] SODIUM SALT
polyinosinic-polycytidylic acid sodium
polyI-polyC sodium salt compound solution
POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT
POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT
POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT
POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT USP/EP/BP
Polyinosinic–polycytidylic Acid Sodium Salt（Poly I:C ）
Polyi polycytidylic acid sodium salt(Poly I:C) (PIC)
Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double
Oligochitosan-kanamycin-polyI-polyC sodium salt compound solution
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C19H27N7O16P2 | [MDL Number]
MFCD00131984 | [MOL File]
42424-50-0.mol | [Molecular Weight]
671.41 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
H2O: soluble10mg/mL | [form ]
lyophilized powder | [color ]
White to off-white | [biological source]
synthetic (organic) | [Water Solubility ]
Water : 10 mg/mL (Need ultrasonic and warming) | [InChIKey]
ACEVNMQDUCOKHT-WOQDZEJINA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r| |
| Hazard Information | Back Directory | [Description]
Polyinosinic-polycytidylic acid sodium salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist. | [Uses]
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
| [Biological Activity]
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis. | [in vivo]
Polyinosinic-polycytidylic acid treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid[1]. | [IC 50]
TLR3 | [storage]
Store at -20°C |
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