| Identification | Back Directory | [Name]
N-(3,4-dichlorophenyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide | [CAS]
424794-91-2 | [Synonyms]
Monoamine Oxidase B inhibitor 4
N-(3,4-dichlorophenyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide
1,4-Benzodioxin-6-carboxamide, N-(3,4-dichlorophenyl)-2,3-dihydro- | [Molecular Formula]
C15H11Cl2NO3 | [MOL File]
424794-91-2.mol | [Molecular Weight]
324.16 |
| Hazard Information | Back Directory | [Uses]
Monoamine Oxidase B inhibitor 4 (compound 1l) is a selective inhibitor of human monoamine oxidase-B (hMAO-B) (IC50=8.3 nM). Monoamine Oxidase B inhibitor 4 also has anti-neuroinflammatory and low neurotoxicity. Monoamine Oxidase B inhibitor 4 can inhibit the release of NO, TNF-α and IL-1β stimulated by LPS and Aβ1-42, and can also attenuate Aβ(1-42)-induced cytotoxicity[1]. | [References]
[1] Sun D, et al. Benzodioxane Carboxamide Derivatives As Novel Monoamine Oxidase B Inhibitors with Antineuroinflammatory Activity[J]. ACS Medicinal Chemistry Letters, 2024. |
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