| Identification | Back Directory | [Name]
ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate | [CAS]
425629-94-3 | [Synonyms]
PfDHODH-IN-2
ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate
3-Thiophenecarboxylic acid, 2-[(4-chlorophenyl)amino]-4,5-dihydro-4-oxo-, ethyl ester | [Molecular Formula]
C13H12ClNO3S | [MDL Number]
MFCD02149613 | [MOL File]
425629-94-3.mol | [Molecular Weight]
297.76 |
| Hazard Information | Back Directory | [Description]
KUN29943 is a Novel Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. This product has no formal name. | [Uses]
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1]. | [References]
[1] Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24. DOI:10.1021/jm400938g |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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