| Identification | Back Directory | [Name]
PD 150,606 | [CAS]
426821-41-2 | [Synonyms]
3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto- | [Molecular Formula]
C9H7IO2S | [MDL Number]
MFCD00949076 | [MOL File]
426821-41-2.mol | [Molecular Weight]
306.12 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes.
A cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes. | [Definition]
ChEBI: (Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid is an organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer). It has a role as a calpain inhibitor and an apoptosis inhibitor. It is an organoiodine compound, a member of cinnamic acids and a thioenol. It is functionally related to a trans-cinnamic acid. | [Biological Activity]
Cell permeable: yes''Primary Target
Calpain-1''Product does not compete with ATP.''Reversible: no''Target Ki: 210 nM for calpain-1 and 370 nM for calpain-2 | [storage]
+4°C |
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