| Identification | Back Directory | [Name]
GEODIN | [CAS]
427-63-4 | [Synonyms]
GEODIN
d-Geodin
(+)-ESTIN
(+)-Form methyl ester
methyl 5,7-dichloro-4-hydroxy-5'-methoxy-6-methyl-3,3'-dioxospiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate
methyl 5,7-dichloro-4-hydroxy-5'-methoxy-6-methyl-3,3'-dioxo-spiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate
5,7-dichloro-4-hydroxy-3,3'-diketo-5'-methoxy-6-methyl-spiro[benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylic acid methyl ester
SPIRO[BENZOFURAN-2(3H),1'-[2,5]CYCLOHEXADIENE]-2'-CARBOXYLIC ACID, 5,7-DICHLORO-4-HYDROXY-6'-METHOXY-6-METHYL-3,4'-DIOXO-, METHYL ESTER
(R)-5,7-Dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester
(1R)-3',4-Dioxo-4'-hydroxy-5',7'-dichloro-6-methoxy-6'-methylspiro[2,5-cyclohexadiene-1,2'(3'H)-benzofuran]-2-carboxylic acid methyl ester
(1R)-3',4-Dioxo-4'-hydroxy-5',7'-dichloro-6'-methyl-6-methoxyspiro[2,5-cyclohexadiene-1,2'(3'H)-benzofuran]-2-carboxylic acid methyl ester
(1'R)-3,4'-Dioxo-5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester
Estin, (+)-5,7-dichloro-4-hydroxy-6-methoxy-6-methyl-3,4-dioxo-spiro[benzofuran-2(3H),1-[2,5]cyclohexadiene]-2-carboxylic acid methyl ester | [Molecular Formula]
C17H12Cl2O7 | [MDL Number]
MFCD00600308 | [MOL File]
427-63-4.mol | [Molecular Weight]
399.18 |
| Chemical Properties | Back Directory | [Melting point ]
235℃ | [alpha ]
D +140° (c = 0.8) | [Boiling point ]
652.1±55.0 °C(Predicted) | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: soluble; DMSO: soluble; Ethyl Acetate: soluble; Methanol: soluble | [form ]
A solid | [pka]
5.17±0.60(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
(+)-Geodin is a fungal metabolite. It increases the fibrinolytic activity of bovine aortic endothelial cells (BAECs) when used at concentrations ranging from 50 to 150 μM. (+)-Geodin (1-100 μg/ml) also increases 2-deoxyglucose uptake by rat adipocytes. | [Uses]
Geodin is an inhibitor of plasminogen activator inhibitor (PAI-1). | [storage]
Store at -20°C | [References]
[1] C SHINOHARA. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B.[J]. Journal of Antibiotics, 2000, 53 3: 262-268. DOI: 10.7164/antibiotics.53.262
[2] SEIICHI SATO. Identification and Preliminary SAR Studies of (+)-Geodin as a Glucose Uptake Stimulator for Rat Adipocytes[J]. Journal of Antibiotics, 2005, 58 9: 583-589. DOI: 10.1038/ja.2005.79 |
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