| Identification | Back Directory | [Name]
Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester | [CAS]
427878-70-4 | [Synonyms]
Ethyl 4-hydroxy-5-Methylp...
ethyl 5-methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazin...
Ethyl 4-hydroxy-5-Methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
Ethyl 4-hydroxy-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
5-methyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
ethyl 5-methyl-4-oxo-3H,4H-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
Ethyl 1,4-dihydro-5-methyl-4-oxo-pyrrolo2,1-f1,2,4triazin-6-carboxylate
Ethyl 1,4-dihydro-5-methyl-4-oxopyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
ethyl 3,4-dihydro-5-methyl-4-oxopyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
Ethyl 5-methyl-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
ethyl 5-Methyl-4-oxo-1,4-dihydropyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
Ethyl 5-Methyl-4-oxo-1,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
ethyl 5-Methyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
Ethyl5-methyl-4-oxo-3,4-dihydropyrrolo[2,1-f]-1,2,4-triazine-6-carboxylate,97%
ethyl 4-hydroxy-5-Methyl -4a,5-dihydro pyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
1,4-Dihydro-5-methyl-4-oxo-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester
5-Methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester
Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester
Ethyl ester 1,4-dihydro-5-methyl-4-oxo-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 97+% | [Molecular Formula]
C10H11N3O3 | [MDL Number]
MFCD12408334 | [MOL File]
427878-70-4.mol | [Molecular Weight]
221.213 |
| Hazard Information | Back Directory | [Synthesis]
1. The compound (CAS: 77287-34-4) was mixed with diethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate in formamide (8 mL) and 20 wt% acetic acid (2 g) was added.
2. The reaction mixture was heated at 120°C for 24 hours.
3. Upon completion of the reaction, it was cooled to room temperature and water (32 mL) was slowly added to precipitate the target product, ethyl 5-methyl-4-oxo-3,4-dihydropyrrolo[1,2-F][1,2,4]triazine-6-carboxylate.
4. The precipitated solid was collected by filtration and washed with ethyl acetate (EtOAc).
5. Drying gave the target compound as a yellow solid in 90% yield. | [References]
[1] Patent: US2006/235020, 2006, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 4 - 16
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 21, p. 4774 - 4779
[4] Patent: US2006/3967, 2006, A1. Location in patent: Page/Page column 8
[5] Patent: US2006/229449, 2006, A1. Location in patent: Page/Page column 6 |
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