| Identification | Back Directory | [Name]
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline | [CAS]
42835-89-2 | [Synonyms]
6-Fluoro-1
6-fluoro-tetrahydro-quinaldine
4-tetrahydro-2-Methylquinoline
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
1,2,3,4-Tetrahydro-6-fluoro-2-Methylquinoline
1,2,3,4-Tetrahydro-2-methyl-6-fluoroquinoline
2-Methyl-6-fluoro-1,2,3,4-tetrahydroquinoline
Quinoline, 6-fluoro-1,2,3,4-tetrahydro-2-methyl-
6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99
6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 99%
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline,98% | [EINECS(EC#)]
255-963-1 | [Molecular Formula]
C10H12FN | [MDL Number]
MFCD00040976 | [MOL File]
42835-89-2.mol | [Molecular Weight]
165.21 |
| Chemical Properties | Back Directory | [Appearance]
white to yellowish crystalline low melting solid | [Melting point ]
31-33°C | [Boiling point ]
254.6±29.0 °C(Predicted) | [density ]
1.0416 (estimate) | [Fp ]
>110°C | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.21±0.40(Predicted) | [color ]
Off-White to Pale Yello | [Optical Rotation]
1.30°(C=0.01g/ml CHCL3) | [CAS DataBase Reference]
42835-89-2 |
| Hazard Information | Back Directory | [Chemical Properties]
white to yellowish crystalline low melting solid | [Uses]
Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents | [Synthesis]
General procedure for the synthesis of 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline from 6-fluoro-2-methylquinoline: in a round-bottomed flask, pre-dried in an oven, a magnetic stirrer was added, followed by the sequential addition of 6-fluoro-2-methylquinoline (0.1 mmol), PCCP (1 mol%), Hantzsch dihydropyridine (3.0 equiv), and CHCl3 (2 mL). The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent of hexane/EtOAc (20:1, v/v) to afford the target product 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline. | [References]
[1] Synlett, 2008, # 6, p. 900 - 902
[2] Tetrahedron Letters, 2017, vol. 58, # 21, p. 2050 - 2053
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 11, p. 1183 - 1187
[4] Chemistry - A European Journal, 2015, vol. 21, # 14, p. 5370 - 5379
[5] Journal of the American Chemical Society, 2015, vol. 137, # 36, p. 11718 - 11724 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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