| Identification | Back Directory | [Name]
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea | [CAS]
428478-94-8 | [Synonyms]
cyt-PTPε Inhibitor-1
1-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-3-(4-methylphenyl)urea
N-{5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}-N'-(4-methylphenyl)urea
Urea, N-[5-[(2,4-dimethylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]-N'-(4-methylphenyl)- | [Molecular Formula]
C19H20N4O2S | [MDL Number]
MFCD02639412 | [MOL File]
428478-94-8.mol | [Molecular Weight]
368.45 |
| Chemical Properties | Back Directory | [density ]
1.319±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
7.07±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
cyt-PTPε Inhibitor-1 is a potent cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) inhibitor, binds to the catalytic domain of cyt-PTPε, blocks c-Src activation (dephosphorylation of c-Src), and exhibits anti-osteoclastic activity[1]. | [References]
[1] Ku B, et al. Identification of N-(5-(phenoxymethyl)-1,3,4-thiadiazol-2-yl)acetamide derivatives as novel protein tyrosine phosphatase epsilon inhibitors exhibiting anti-osteoclastic activity. ioorg Med Chem. 2018 Oct 1;26(18):5204-5211. DOI:10.1016/j.bmc.2018.09.022 |
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