| Identification | Back Directory | [Name]
10H-1,3-Dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 7-ethyl-7-hydroxy-14-(hydroxymethyl)-, (7S)- | [CAS]
428816-69-7 | [Synonyms]
10H-1,3-Dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 7-ethyl-7-hydroxy-14-(hydroxymethyl)-, (7S)- | [Molecular Formula]
C22H18N2O7 | [MOL File]
428816-69-7.mol | [Molecular Weight]
422.39 |
| Chemical Properties | Back Directory | [Boiling point ]
878.5±65.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.18±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
7-Hydroxymethyl-10,11-MDCPT is a payload that can be used for ADC synthesis[1]. | [References]
[1] Cai JQ, Human anti-human HER3 antibodies and ADCs or drug conjugates for therapy, prevention and diagnosis of cancer or infection. 2023. WO2023143263
[2] Wadkins RM, et al. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Res. 2004 Sep 15;64(18):6679-83. DOI:10.1158/0008-5472.CAN-04-1885 |
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