| Identification | Back Directory | [Name]
CATHEPSIN G INHIBITOR I | [CAS]
429676-93-7 | [Synonyms]
CATHEPSIN G INHIBITOR I
BOROXIN, TRIS(1-METHYLETHYL)
Phosphonic acid, P-[2-[3-[[(1-benzoyl-4-piperidinyl)methylamino]carbonyl]-2-naphthalenyl]-1-(1-naphthalenyl)-2-oxoethyl]- | [Molecular Formula]
C36H33N2O6P | [MDL Number]
MFCD28137715 | [MOL File]
429676-93-7.mol | [Molecular Weight]
620.64 |
| Chemical Properties | Back Directory | [Boiling point ]
912.0±75.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
1.51±0.10(Predicted) | [color ]
White to off-white | [Sensitive ]
Light Sensitive | [InChIKey]
GNOZQRKYZJSIPZ-UHFFFAOYSA-N | [SMILES]
[P](=O)(O)(O)C(c5c6c(ccc5)cccc6)C(=O)c1cc2c(cc1C(=O)N(C3CCN(CC3)C(=O)c4ccccc4)C)cccc2 |
| Hazard Information | Back Directory | [Description]
Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G (IC50 = 53 nM). It weakly inhibits or has no effect on related proteases, including chymotrypsin, thrombin, plasmin, trypsin, tryptase, and elastase. | [Uses]
Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G. | [target]
cathepsins G | [References]
[1] greco mn, hawkins mj, powell et, almond hr jr, corcoran tw, de garavilla l, kauffman ja, recacha r, chattopadhyay d, andrade-gordon p, maryanoff be. nonpeptide inhibitors of cathepsin g: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. j am chem soc. 2002;124(15):3810-1. |
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