| Identification | Back Directory | [Name]
N-HYDROXY-BUTYRAMIDINE | [CAS]
4312-91-8 | [Synonyms]
NSC 111681
NSC 158654
Butyrylhydroxamate
N-Hydroxybutyramide
Butyrohydroximic acid
N-HYDROXY-BUTYRAMIDINE
N-Butyrylhydroxylamine
Butyrylhydroxamic acid
Butanamide, N-hydroxy- | [Molecular Formula]
C4H9NO2 | [MDL Number]
MFCD09931604 | [MOL File]
4312-91-8.mol | [Molecular Weight]
103.12 |
| Chemical Properties | Back Directory | [Melting point ]
125-127℃ | [storage temp. ]
-20°C | [solubility ]
H2O: ≥25mg/mL | [form ]
powder | [color ]
white to tan | [Water Solubility ]
H2O: ≥25mg/mL | [InChI]
1S/C4H9NO2/c1-2-3-4(6)5-7/h7H,2-3H2,1H3,(H,5,6) | [InChIKey]
CCBCHURBDSNSTJ-UHFFFAOYSA-N | [SMILES]
CCCC(=O)NO |
| Hazard Information | Back Directory | [Uses]
Butyrylhydroxamic acid (N-Hydroxybutanamide) is a potent inhibitor of histone deacetylase (HDAC). Butyrylhydroxamic acid enhances memory in behavioral models of rodents and can be used as memory enhancers, mood stabilizers, and β-chain hemoglobin disease studies[1]. | [Biological Activity]
Butyryl hydroxamic acid is a cell permeable HDAC inhibitor. Butyryl hydroxamic acid has similar potency against class I HDAC family members as 4-Phenylbutyryl hydroxamic acid (SML0026)but is approximately 5-10 fold less potent against class IIa enzymes than 4-Phenylbutyryl hydroxamic acid. | [References]
[1] Ruan LT, et al. A novel amidase from Brevibacterium epidermidis ZJB-07021: gene cloning, refolding and application in butyrylhydroxamic acid synthesis. J Ind Microbiol Biotechnol. 2016 Aug;43(8):1071-83. DOI:10.1007/s10295-016-1786-y |
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