| Identification | Back Directory | [Name]
Ethanone, 1-[3-[(2E)-3,7-dimethyl-2,6-octadienyl]-2,4,6-trihydroxyphenyl]- | [CAS]
43230-43-9 | [Synonyms]
tHGA
t-HGA
Ethanone, 1-[3-[(2E)-3,7-dimethyl-2,6-octadienyl]-2,4,6-trihydroxyphenyl]- | [Molecular Formula]
C18H24O4 | [MOL File]
43230-43-9.mol | [Molecular Weight]
304.38 |
| Hazard Information | Back Directory | [Description]
tHGA is a potent lipoxygenase (LOX) inhibitor. | [Uses]
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC50 value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC50 value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC50 value of 0.40 μM[1]. | [References]
[1] Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase |
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