| Identification | Back Directory | [Name]
PP7 | [CAS]
433238-84-7 | [Synonyms]
PP7
inhibit,PP 7,PP7,Influenza Virus,Inhibitor,PP-7
3,5-Pyrazolidinedione, 1-(3,4-dichlorophenyl)-4-[(4-ethoxyphenyl)methylene]- | [Molecular Formula]
C18H14Cl2N2O3 | [MDL Number]
MFCD02909258 | [MOL File]
433238-84-7.mol | [Molecular Weight]
377.22 |
| Hazard Information | Back Directory | [Uses]
PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes[1]. | [References]
[1] Yuan S, et al. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface. Antiviral Res. 2017 Jan;137:58-66. DOI:10.1016/j.antiviral.2016.11.005 |
|
|