| Identification | Back Directory | [Name]
N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide | [CAS]
439575-02-7 | [Synonyms]
BMS 509744
BMS-509744
(BMS 509744
N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide
N-[5-[[5-[(4-Acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]benzamide
Benzamide, N-[5-[[5-[(4-acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]- | [Molecular Formula]
C32H41N5O4S2 | [MDL Number]
MFCD18782598 | [MOL File]
439575-02-7.mol | [Molecular Weight]
623.83 |
| Hazard Information | Back Directory | [Uses]
BMS 509744, is a potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitor. It reduces HIV infection of primary CD4+ T cells, and in vitro. | [Definition]
ChEBI: N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide is a member of benzamides. | [Biological Activity]
Cell permeable: yes', 'Primary Target
ITK', 'Target IC50: 19 nM for ITK | [in vivo]
BMS-509744 and BMS-488516 suppress the production of IL-2 induced by anti-T-cell receptor antibody administered to mice. BMS-509744 exhibits a 50% inhibitory capacity when dosed at 50 mg/kg, irrespective of the amount of induction antibody. BMS-509744 also significantly diminishes lung inflammation in a mouse model of ovalbumin-induced allergy/asthma[1]. |
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BOC Sciences
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https://www.bocsci.com |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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