| Identification | Back Directory | [Name]
BTA-1 | [CAS]
439858-28-3 | [Synonyms]
4-(Benzo[d]thiazol-2-yl)-N-methylaniline
4-(1,3-Benzothiazol-2-yl)-N-methylaniline
(4-Benzothiazol-2-yl-phenyl)-methyl-amine
Benzenamine, 4-(2-benzothiazolyl)-N-methyl-
BTA-1,2-(4′-Methylaminophenyl)benzothiazole | [Molecular Formula]
C14H12N2S | [MDL Number]
MFCD04974146 | [MOL File]
439858-28-3.mol | [Molecular Weight]
240.32 |
| Chemical Properties | Back Directory | [Boiling point ]
415.5±47.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble ~10mg/mL | [form ]
solid | [pka]
2.58±0.12(Predicted) | [color ]
yellow |
| Hazard Information | Back Directory | [Description]
BTA-1 is an uncharged derivative of thioflavin-T. It has high affinity for Aβ fibrils and shows very good brain entry and clearance. | [Uses]
BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has a high affinity for Aβ fibrils and shows very good brain penetration and clearance[1]. | [Biochem/physiol Actions]
BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier. | [References]
[1] Klunk WE, et al. The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci. 2003;23(6):2086-2092. DOI:10.1523/JNEUROSCI.23-06-02086.2003 |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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