| Identification | Back Directory | [Name]
CeMMEC1 | [CAS]
440662-09-9 | [Synonyms]
CeMMEC1
cemmecl
CeMMEC1(free base)
4-Isoquinolinecarboxamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo- | [Molecular Formula]
C19H16N2O4 | [MDL Number]
MFCD02939849 | [MOL File]
440662-09-9.mol | [Molecular Weight]
336.34 |
| Chemical Properties | Back Directory | [Boiling point ]
590.1±50.0 °C(Predicted) | [density ]
1.386±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
11.38±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (Kd = 1.8 μM; IC50 = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. This compound synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. | [Uses]
CeMMEC1, shows high affinity for TAF1, and is an inhibitor of BRD4. | [storage]
Store at -20°C | [References]
[1] SARA SDELCI. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk[J]. Nature chemical biology, 2016, 12 7: 504-510. DOI: 10.1038/nchembio.2080 |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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