| Identification | Back Directory | [Name]
(E)-4-(2-((2-methyl-1H-indol-3-yl)methylene)hydrazinyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine | [CAS]
441742-93-4 | [Synonyms]
pyrimidine-indole hybrid
(E)-4-(2-((2-methyl-1H-indol-3-yl)methylene)hydrazinyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
4-{(2E)-2-[(2-methyl-1H-indol-3-yl)methylidene]hydrazinyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine | [Molecular Formula]
C20H19N5S | [MOL File]
441742-93-4.mol | [Molecular Weight]
361.46 |
| Hazard Information | Back Directory | [Description]
PIH is an inhibitor of ciliogenesis through microtubule destabilization. It acts by antagonizing Hh signaling by repressing cilia biogenesis and disassembly of alpha tubulin in its stabilized form. | [Uses]
Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics[1]. | [References]
[1] Hedgehog Antagonist Pyrimidine-Indole Hybrid Molecule Inhibits Ciliogenesis through Microtubule Destabilisation DOI:10.1002/cbic.201700631 |
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