| Identification | Back Directory | [Name]
4-(4-METHANESULFONYL-PIPERAZIN-1-YL)-PHENYLAMINE | [CAS]
442549-42-0 | [Synonyms]
AKOS BB-8668
ASISCHEM Y80106
[4-(4-mesylpiperazin-1-yl)phenyl]amine
4-(4-methylsulfonyl-1-piperazinyl)aniline
4-(4-METHANESULFONYL-PIPERAZIN-1-YL)-PHENYLAMINE
{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}amine
Benzenamine, 4-[4-(methylsulfonyl)-1-piperazinyl]-
4-(4-Mesylpiperazin-1-yl)aniline, 1-(4-Aminophenyl)-4-(methylsulphonyl)piperazine | [Molecular Formula]
C11H17N3O2S | [MDL Number]
MFCD03848236 | [MOL File]
442549-42-0.mol | [Molecular Weight]
255.34 |
| Chemical Properties | Back Directory | [Boiling point ]
475.7±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
7.69±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
Procedure: general procedure for the synthesis of 4-(4-methanesulfonyl-piperazin-1-yl)-aniline from 4-(4-nitrophenyl)-1-methanesulfonyl-piperazine.
Step 1: 10% Pd-C (100 mg) was added to a methanolic solution of 1-(4-nitrophenyl)-piperidine-4-carboxylic acid amide (350 mg, 0.0035 mol) at room temperature and hydrogen gas was passed. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent 5% methanol:chloroform). Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to give 270 mg (86% yield) of 4-(4-methylsulfonyl-piperazin-1-yl)-aniline. | [References]
[1] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 118-119
[2] Patent: US2003/13708, 2003, A1
[3] Patent: US2004/87575, 2004, A1
[4] Patent: US2004/110745, 2004, A1
[5] Patent: WO2005/75461, 2005, A1. Location in patent: Page/Page column 93-94 |
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SynAsst Chemical.
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DebyeTec.com Inc.
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Energy Chemical
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