| Identification | Back Directory | [Name]
cis-5-({[1-(4-chlorophenyl)-1H-tetraazol-5-yl]sulfanyl}acetyl)-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole | [CAS]
442656-02-2 | [Synonyms]
AG-205
AG-205
(AG205
AG-205 >=98% (HPLC)
cis-5-({[1-(4-chlorophenyl)-1H-tetraazol-5-yl]sulfanyl}acetyl)-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
Ethanone, 2-[[1-(4-chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-
cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone | [Molecular Formula]
C22H23ClN6OS | [MOL File]
442656-02-2.mol | [Molecular Weight]
454.98 |
| Chemical Properties | Back Directory | [Boiling point ]
671.466±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.469±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble to 50 mM in DMSO | [form ]
powder | [pka]
9.121±0.20(predicted) | [color ]
off-white to brown |
| Hazard Information | Back Directory | [Uses]
AG-205 has been used to investigate the neuroprotective effects of norgestrel on stressed photoreceptors. It has also been used to study the effect of blocking progesterone receptor membrane component 1 in 661W cells. | [Biochem/physiol Actions]
AG-205 is a Pgrmc1 (progesterone receptor membrane component 1) inhibitor. AG-205 alters the spectroscopic properties of the Pgrmc1-heme complex. AG-205 inhibits cancer cell viability and cancer cell progression. acting preferentially on Pgrmc1-expressing cells. | [storage]
Store at +4°C |
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Sigma-Aldrich
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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