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4431-42-9

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4431-42-9 Structure

4431-42-9 Structure
IdentificationBack Directory
[Name]

Isopedicin
[CAS]

4431-42-9
[Synonyms]

Isopedicin
6-Hydroxy-5,7,8-trimethoxyflavanone
4H-1-Benzopyran-4-one, 2,3-dihydro-6-hydroxy-5,7,8-trimethoxy-2-phenyl-, (2S)-
[Molecular Formula]

C18H18O6
[MDL Number]

MFCD23103659
[MOL File]

4431-42-9.mol
[Molecular Weight]

330.33
Chemical PropertiesBack Directory
[Melting point ]

105 °C
[Boiling point ]

552.9±50.0 °C(Predicted)
[density ]

1.278±0.06 g/cm3(Predicted)
[pka]

9.19±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity[1].
[References]

[1] Hwang TL, et al. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic Biol Med. 2009 Feb 15;46(4):520-8. DOI:10.1016/j.freeradbiomed.2008.11.014
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