| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(phenylmethyl)amino]- | [CAS]
444287-56-3 | [Synonyms]
E3 ligase Ligand 23
4-(benzylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[(phenylmethyl)amino]-
inhibit,Inhibitor,Cereblon,Aiolos,ubiquitin proteasome,Ligands for E3 Ligase,Ikaros,E3 ligase Ligand 23,E-3 ligase Ligand 23,E3 ligase-recruiting Moiety | [Molecular Formula]
C20H17N3O4 | [MOL File]
444287-56-3.mol | [Molecular Weight]
363.37 |
| Chemical Properties | Back Directory | [Boiling point ]
634.3±55.0 °C(Predicted) | [density ]
1.442±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.68±0.40(Predicted) | [color ]
Yellow to green |
| Hazard Information | Back Directory | [Uses]
E3 ligase Ligand 23 (compound 17-6) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway[1]. | [IC 50]
Cereblon | [References]
[1] Gesine Kerstin VEITS, et al. Cereblon binders for the degradation of ikaros. WO2019191112A1. |
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