| Hazard Information | Back Directory | [Uses]
Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1]. | [in vivo]
Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus)[1]. | Animal Model: | Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT)[1]. | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection, single. | | Result: | Increased DOPA accumulation in the hippocampus with no effect observed in the striatum. |
| [IC 50]
hD4.2 Receptor: 9.0 nM (Ki) | [References]
[1] Pugsley TA, et al. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26. DOI:10.1016/s0278-5846(01)00252-4 |
|
|