| Identification | Back Directory | [Name]
MITOQ | [CAS]
444890-41-9 | [Synonyms]
MitoQ10
Mitoquinol(MITOQ)
Mitoquinone
Discontinued
Mitoquinone | Mitochondria-targeted antioxidant | [Molecular Formula]
C37H44O4P+ | [MDL Number]
MFCD27977560 | [MOL File]
444890-41-9.mol | [Molecular Weight]
583.73 |
| Chemical Properties | Back Directory | [storage temp. ]
-20° | [solubility ]
Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL) | [form ]
waxy solid | [color ]
Brown | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1?Displays beneficial effects in mouse models of Alzheimer’s disease.2?Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.? Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available. | [Uses]
Mitoquinone is a mitochondria-targeted antioxidant. | [References]
1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674
2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703
3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation]
5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation]
6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation]
7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation] |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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