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445000-45-3

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445000-45-3 Structure

445000-45-3 Structure
IdentificationBack Directory
[Name]

N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide
[CAS]

445000-45-3
[Synonyms]

N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide
[Molecular Formula]

C18H12BrNO2S
[MOL File]

445000-45-3.mol
[Molecular Weight]

386.262
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light brown to brown
Hazard InformationBack Directory
[Uses]

BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway[1].
[References]

[1] Yao XG, et al. BBT improves glucose homeostasis by ameliorating cell dysfunction in type 2 diabetic mice. J Endocrinol. 2015 Mar;224(3):327-41. DOI:10.1530/JOE-14-0721
Spectrum DetailBack Directory
[Spectrum Detail]

N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide(445000-45-3)1HNMR
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