| Identification | Back Directory | [Name]
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea | [CAS]
445007-59-0 | [Synonyms]
N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea | [Molecular Formula]
C16H18N2O | [MOL File]
445007-59-0.mol | [Molecular Weight]
254.327 |
| Hazard Information | Back Directory | [Description]
AK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway. | [Uses]
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1]. | [IC 50]
PAK1 | [References]
[1] Ying Zhou, et al. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1-Related Signaling Pathways. Anat Rec (Hoboken). 2019 Sep;302(9):1571-1579. DOI:10.1002/ar.24095 |
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www.specs.net |
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