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4452-06-6

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4452-06-6 Structure

4452-06-6 Structure
IdentificationBack Directory
[Name]

ZM 449829
[CAS]

4452-06-6
[Synonyms]

ZM 449829
JAK3 INHIBITOR V
2'-Acrylonaphthone
naphthyl vinyl ketone
2-NAPHTHYLVINYL KETONE
1-Naphthalen-2-yl-propenone
1-(2-Naphthyl)-2-propen-1-one
1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE
1-(Naphthalen-2-yl)prop-2-en-1-one
2-Propen-1-one, 1-(2-naphthalenyl)-
JAK3 Inhibitor V - CAS 932258 - Calbiochem
[Molecular Formula]

C13H10O
[MDL Number]

MFCD04974535
[MOL File]

4452-06-6.mol
[Molecular Weight]

182.22
Chemical PropertiesBack Directory
[Melting point ]

38-40 °C
[Boiling point ]

319.3±15.0 °C(Predicted)
[density ]

1.093±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Sealed in dry,Store in freezer, under -20°C
[solubility ]

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
[form ]

White waxy solid
[color ]

white
[InChI]

InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
[InChIKey]

FOTCGZPFSUWZBN-UHFFFAOYSA-N
[SMILES]

C(C1=CC=C2C(=C1)C=CC=C2)(=O)C=C
Safety DataBack Directory
[Symbol(GHS) ]

Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
[Signal word ]

Danger
[Hazard statements ]

H301-H311-H331-H341
[Precautionary statements ]

P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

ZM 449829, is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Also inhibits STAT-5 phosphorylation and T-cell proliferation.
[Definition]

ChEBI: 1-(2-naphthalenyl)-2-propen-1-one is a member of naphthalenes.
[Biological Activity]

Cell permeable: no''Product does not compete with ATP.''Reversible: no''pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1
[IC 50]

JAK3: 6.8 (pIC50); JAK1: 4.7 (pIC50); EGFR: 5.0 (pIC50)
[storage]

Desiccate at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

ZM 449829(4452-06-6)1HNMR
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