| Identification | Back Directory | [Name]
hydrochloride | [CAS]
446031-79-4 | [Synonyms]
SSR 180711 hydrochloride
(4-bromophenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate | [Molecular Formula]
ClH | [MDL Number]
MFCD30182319 | [MOL File]
446031-79-4.mol | [Molecular Weight]
36.4609 |
| Hazard Information | Back Directory | [Uses]
SSR 180711 Hydrochloride is a partial agonist at α7 nAChR. It enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. It increases extracellular dopamine levels in rat prefrontal cortex and also exhibits antidepressant-like properties. | [in vivo]
SSR180711 hydrochloride rapidly penetrates into the brain (ID50=8?mg/kg; p.o.). SSR180711 hydrochloride dose-dependently inhibits the specific [3H]α-BTX binding in the mouse brain (ID50=8.3 and 7.5?mg/kg for p.o. and i.p., respectively)[1].
SSR180711 hydrochloride (1-10?mg/kg for i.p.; 10-30 mg/kg for p.o.) dose-dependently increases extracellular acetylcholine (ACh) levels in the hippocampus and prefrontal cortex of freely moving rats[1].
SSR180711 hydrochloride (0.1, 0.3, 1?mg/kg; i.v.) dose-dependently increases firing rate[1].
| [storage]
Store at -20°C |
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