| Identification | Back Directory | [Name]
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE | [CAS]
4465-65-0 | [Synonyms]
Epianhydrotetracycline hydrochloride
4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE
4-Epianhydroustetracycline hydrochloride
4-Epianhydrotetracycline Hydrochloride (50 mg)
4-epianhydrotetracyclinehydrochloride’canbeusedassecondarystandard’
4-Epianhydrotetracycline hydrochloride,97%,'can be used as a secondary standard'
4-Epianhydrotetracycline hydrochloride, 'can be used as a secondary standard', 97%
(4R,4aS,12aS)-4-(DiMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride
(4R,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDROCHLORIDE | [Molecular Formula]
C22H23ClN2O7 | [MDL Number]
MFCD00151455 | [MOL File]
4465-65-0.mol | [Molecular Weight]
462.88 |
| Chemical Properties | Back Directory | [Appearance]
orange powder | [Melting point ]
220 °C
| [storage temp. ]
-20?C Freezer | [solubility ]
DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 0.25 mg/ml | [form ]
Powder | [color ]
Orange | [BRN ]
3840711 | [Major Application]
clinical testing | [InChIKey]
XBSQEFHDCDFNJU-PFRKANOHNA-N | [SMILES]
O[C@@]12C(C(C(=O)N)=C(O)[C@H](N(C)C)[C@]1([H])CC1C(=C3C=CC=C(O)C3=C(O)C=1C2=O)C)=O.Cl |&1:1,9,13,r| | [EPA Substance Registry System]
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4R,4aS,12aS)- (4465-65-0) |
| Hazard Information | Back Directory | [Chemical Properties]
orange powder | [Uses]
An antibiotic derived from Tetracycline. Studies have shown that this derivative can have a 250-fold higher toxicity depending on the system under study. | [Uses]
Epianhydrotetracycline is a secondary degradation product formed by epimerisation of tetracycline and dehydration at the C6 position to aromatise the B ring. Epianhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, epianhdrotetracycline is considered biologically active and is thought responsible for aspects tetracycline toxicity. | [Uses]
Epianhydrotetracycline is a secondary degradation product formed by epimerisation of tetracycline and dehydration at the C6 position to aromatise the B ring. Epianhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, epianhydrotetracycline is considered biologically active and is thought responsible for aspects tetracycline toxicity. |
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