| Identification | Back Directory | [Name]
Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]- | [CAS]
450338-32-6 | [Synonyms]
TH301
Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]- | [Molecular Formula]
C24H24ClN3O4S | [MOL File]
450338-32-6.mol | [Molecular Weight]
485.98 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Waxy solid | [color ]
orange | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChI]
1S/C24H24ClN3O4S/c1-32-19-10-8-18(9-11-19)28-22(20-14-33(30,31)15-21(20)27-28)26-23(29)24(12-2-3-13-24)16-4-6-17(25)7-5-16/h4-11H,2-3,12-15H2,1H3,(H,26,29) | [InChIKey]
DDCUCVXSGYHWRJ-UHFFFAOYSA-N | [SMILES]
O=C(C1(CCCC1)C2=CC=C(Cl)C=C2)NC3=C(CS(C4)(=O)=O)C4=NN3C5=CC=C(OC)C=C5 |
| Hazard Information | Back Directory | [Description]
TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2.? It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics. | [References]
References/Citations: |
|
| Company Name: |
Enzo Biochem Inc
|
| Telephone: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|