452350-43-5

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452350-43-5 Structure

Identification	Back Directory
[Name] BRD-K20733377
[CAS] 452350-43-5
[Synonyms] BRD-K20733377 [1,1′-Biphenyl]-4-carboxamide, N-[4-[(2-pyrimidinylamino)sulfonyl]phenyl]-
[Molecular Formula] C23H18N4O3S
[MOL File] 452350-43-5.mol
[Molecular Weight] 430.48

Chemical Properties	Back Directory
[density ] 1.392±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

Hazard Information	Back Directory
[Uses] BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629)-induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1].
[References] [1] Wong F, et al., Discovering small-molecule senolytics with deep neural networks. Nat Aging. 2023 Jun;3(6):734-750. DOI:10.1038/s43587-023-00415-z

452350-43-5 suppliers list

Company Name:	Jinan Jiuli Biotechnology Co. , Ltd.
Tel:	15865264761
Website:	www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

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