| Identification | Back Directory | [Name]
gossypolone | [CAS]
4547-72-2 | [Synonyms]
1,1',4,4'-Tetrahydro-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-diisopropyl-1,1',4,4'-tetraoxo[2,2'-binaphthalene]-8,8'-dicarbaldehyde
[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',4,4'-tetrahydro-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-1,1',4,4'-tetraoxo- | [Molecular Formula]
C30H26O10 | [MDL Number]
MFCD00133381 | [MOL File]
4547-72-2.mol | [Molecular Weight]
546.52 |
| Chemical Properties | Back Directory | [Melting point ]
256-260 °C(Solv: acetic acid (64-19-7); water (7732-18-5)) | [Boiling point ]
842.1±65.0 °C(Predicted) | [density ]
1.485±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
4.42±0.20(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer[1]. | [References]
[1] Lan L, et al. Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. BMC Cancer. 2018 Aug 10;18(1):809. DOI:10.1186/s12885-018-4704-z |
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