| Identification | Back Directory | [Name]
1-Boc-3-Methylaminopyrrolidine | [CAS]
454712-26-6 | [Synonyms]
1-BOC-3-METHYLAMINOPYRROLIDINE
N-BOC-3-Methylaminopyrrolidine
1-Boc-3-methylaminopyrrolidine ,98%
1-Boc-3-Methylaminopyrrolidine USP/EP/BP
1-(tert-Butyloxycarbonyl)-3-methylaminopyrro
3-Methylamino-1-tert-butoxycarbonylpyrrolidine
1-(tert-Butyloxycarbonyl)-3-methylaminopyrrolidine
tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate
3-METHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-(Methylamino)-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
1-Pyrrolidinecarboxylic acid, 3-(MethylaMino)-, 1,1-diMethylethyl ester
1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester(9CI) | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD06656606 | [MOL File]
454712-26-6.mol | [Molecular Weight]
200.28 |
| Chemical Properties | Back Directory | [Boiling point ]
269 °C | [density ]
1.03 | [Fp ]
117 °C | [storage temp. ]
Room temperature. | [form ]
solid | [pka]
10.02±0.20(Predicted) | [Appearance]
Colorless to light yellow Liquid | [Optical Rotation]
-1.16°(C=0.50g/100mL, CHCL3, 20°C, 589nm) | [InChI]
1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-5-8(7-12)11-4/h8,11H,5-7H2,1-4H3 | [InChIKey]
OKUCEQDKBKYEJY-UHFFFAOYSA-N | [SMILES]
CNC1CCN(C1)C(=O)OC(C)(C)C |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
25-50 | [Safety Statements ]
45-61 | [RIDADR ]
UN2811 | [WGK Germany ]
WGK 3 | [HazardClass ]
8 | [HS Code ]
29339900 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: To a solution of 1-(tert-butoxycarbonyl)pyrrolidin-3-one (74 g, 0.4 mol) in methanol (450 mL) was slowly added a methanolic solution of methylamine (137.8 g, 1.2 mol) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, sodium borohydride (15.2 g, 0.4 mol) was added in batches and stirring was continued for 1 hour at room temperature. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was extracted by partitioning between dichloromethane (3 x 500 mL) and water (300 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-methylaminopyrrolidine (74 g, 92.5% yield), which could be used in the next reaction without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.54 (m, 4H), 3.29 (m, 2H), 2.45 (s, 3H), 2.20 (m, 1H), 1.38 (s, 9H). | [References]
[1] Patent: WO2009/76387, 2009, A1. Location in patent: Page/Page column 42
[2] Patent: US2015/252021, 2015, A1. Location in patent: Paragraph 0307; 0308
[3] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 108-109
[4] ChemCatChem, 2018, vol. 10, # 3, p. 510 - 514
[5] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 101; 106 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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