| Identification | Back Directory | [Name]
APOLIPOPROTEIN E, ISOFORM E2, HUMAN, RECOMBINANT | [CAS]
NoCAS | [Synonyms]
Apo E2
RHAPO E2
HUMAN APOE2
APO-E2, HUMAN
APOLIPOPROTEIN E2
APO-E2, HUMAN R-DNA
APOLIPOPROTEIN E2 HUMAN
HUMAN APOLIPOPROTEIN E2
APOLIPOPROTEIN E, HUMAN
APOLIPOPROTEIN E-II, HUMAN
APOLIPOPROTEIN E-II, HUMAN R-DNA
APOLIPOPROTEIN E, ISOFORM E2, HUMAN, RECOMBINANT | [MDL Number]
MFCD00285513 |
| Hazard Information | Back Directory | [Uses]
Apolipoprotein E, human has been used as a standard for the quantification of ApoE protein in the sucrose density gradient (SDG) fractions and the unfractionated brain homogenates using an in-house developed sandwich enzyme-linked immunosorbent assay (ELISA). It has also been used in western blotting to assess its exogenous effects on low-density lipoprotein (LDL)-heparin interactions. | [Biological Activity]
In addition to facilitating solubilization of lipidsapolipoproteins help to maintain the structural integrity of lipoproteinsserve as ligands for lipoprotein receptorsand regulate the activity of enzymes involved in lipid metabolism. Apolipoprotein E (ApoE) plays an important role in lipid metabolism. It′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cellswhich is an essential step during normal lipid metabolism. It also binds with the LDL receptor (Apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. |
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