457-60-3

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457-60-3 Structure

Identification	Back Directory
[Name] Neoarsphenamine
[CAS] 457-60-3
[Synonyms] 914 arsevan Novarsan miarsenol Ai3-14551 collunovar collunover neo-i.c.i. novarsenol neoarsoluin neosalvarsan neoarsfenamin Vetarsenobillon NEOARSPHENAMINE novarsenobenzol novarsenobillon Neoarsphenaminum Einecs 207-273-7 Neo-gargarol liquidum Neoarsphenamine USP/EP/BP amino)methyl)ester,monosodiumsalt arsphenaminemethylenesulfoxylicacidsodiumsalt 3,3’-diamino-4,4’-dihydroxyarsenobenzenemethylenesulfoxylatesodium ((5-(3-amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanolsulfoxylateso sulfoxylicacid,mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydroxyphenyl) ((5-(3-Amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanol sulfoxylate sodium sodium,[5-(3-amino-4-hydroxyphenyl)arsanylidenearsanyl-2-hydroxyanilino]methanesulfinate Sodium [[5-(3-amino-4-hydroxyphenyl)arsanylidenearsanyl-2-hydroxyphenyl]amino]methanesulfinate
[EINECS(EC#)] 207-273-7
[Molecular Formula] C13H13As2N2NaO4S
[MDL Number] MFCD00864841
[MOL File] 457-60-3.mol
[Molecular Weight] 466.15

Chemical Properties	Back Directory
[Uses] Treatment against syphilis.
[CAS DataBase Reference] 457-60-3

Safety Data	Back Directory
[Hazard Codes ] Xn
[Risk Statements ] 22
[Safety Statements ] 24/25-36
[Safety Profile] Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, , NOx, Na2O,and SOx,. See also ARSENIC COMPOUNDS.
[Toxicity] guinea pig,LDLo,intraperitoneal,75mg/kg (75mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.

Raw materials And Preparation Products	Back Directory
[Raw materials] Sodium formaldehydesulfoxylate dihydrate-->arsenobenzene

Hazard Information	Back Directory
[Description] Neosalvarsan (compound 914) is a salt derivative of Salvarsan and is water soluble, which showed reduced side effects .Later work showed that neither Salvarsan nor Neosalvarsan was the active pharmaceutical ingredient (API).
[Chemical Properties] Yellow powder or granules. Easily oxidized in air, accelerated by high temperatures. Soluble in water, insoluble in ethanol, chloroform, and ether.

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