| Identification | Back Directory | [Name]
ethyl 4-((3-(dimethylamino)propyl)imino)-6,8-dimethyl-1,4-dihydroquinoline-3-carboxylate | [CAS]
457937-39-2 | [Synonyms]
BMH9
BMH-9
BMH 9
ethyl 4-((3-(dimethylamino)propyl)imino)-6,8-dimethyl-1,4-dihydroquinoline-3-carboxylate | [Molecular Formula]
C19H27N3O2 | [MOL File]
457937-39-2.mol | [Molecular Weight]
329.44 |
| Hazard Information | Back Directory | [Description]
BMH-9 is an inhibitor of RNA polymerase I. It acts by causing nucleolar stress and showing potent anticancer activity across many tumor types. | [Uses]
BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2)[1]. BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models[1]. | [References]
[1] Lander HM, et al., Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans. US20180214413. |
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