| Identification | Back Directory | [Name]
Uzarigenin | [CAS]
466-09-1 | [Synonyms]
Osin
UZARIGENIN
ODORIGENIN B
3-beta-14-beta-5-allo-cardenolid
3β,14-Dihydroxy-5α-card-20(22)-enolide
Card-20(22)-enolide,3,14-dihydroxy-, (3b,5a)-
3-beta,14-dihydroxy-5-alpha-card-20(22)-enolide | [EINECS(EC#)]
207-373-0 | [Molecular Formula]
C23H34O4 | [MDL Number]
MFCD00064896 | [MOL File]
466-09-1.mol | [Molecular Weight]
374.51 |
| Chemical Properties | Back Directory | [Melting point ]
240-256° | [alpha ]
D20 +10.5° (c = 1.056 in alc) | [Boiling point ]
549.3±50.0 °C(Predicted) | [density ]
1.231±0.06 g/cm3(Predicted) | [pka]
14.93±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1]. | [References]
[1] Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79. DOI:10.1021/acs.jnatprod.8b00630 |
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