4663-99-4

15074-61-0

4663-99-4

The synthesis of pyridine-3,5-dicarboxamide was carried out according to Carelli's modified method. [38] Dichloromethane was used as a co-solvent to increase the reaction interface and to prevent foaming on addition of solids. Pyridine-3,5-dicarbonyl chloride (1.61 g, 7.89 mmol) was dissolved in dichloromethane (10 mL) with vigorous stirring at room temperature and the reaction was added slowly dropwise over a period of 1 hour. The reaction mixture was filtered through diatomaceous earth and subsequently recrystallized in ethanol/water (50:50) mixed solvent. Light yellow flaky crystals of pyridine-3,5-dicarboxamide (910 mg, 3.51 mmol, 70% yield) were obtained (Rf = 0, unfolding agent dichloromethane/methanol 10:1, melting point 115 °C).