| Identification | Back Directory | [Name]
GRAYANOTOXIN III | [CAS]
4678-45-9 | [Synonyms]
andromedol
GRAYANOTOXIN III
deacylasebotoxini
deacetylandromedotoxin
Grayanotoxin III Hemi(ethyl acetate)
GRAYANOTOXIN 3.1/2 ETHYL ACETATE ADDUCT
(14R)-Grayanotoxane-3β,5,6β,10,14,16-hexol
GRAYANOTOXIN III HEMI(ETHYL ACETATE) ADDUCT
Grayanotoxane-3,5,6,10,14,16-hexol,(3b,6b,14R)-
Grayanotoxane-3,5,6,10,14,16-hexol, (3β,6β,14R)-
6,10,14,16-hexol,(3-beta,6-beta,14r)-grayanotoxane-5
4,8-tetramethyl-,(2s,3as,4r,4ar,7r,8r,9as,11r,11ar,12r)-1 | [Molecular Formula]
C20H34O6 | [MDL Number]
MFCD01319138 | [MOL File]
4678-45-9.mol | [Molecular Weight]
370.48 |
| Chemical Properties | Back Directory | [Melting point ]
218 °C (decomp) | [Boiling point ]
552.6±50.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml | [pka]
13.79±0.70(Predicted) |
| Hazard Information | Back Directory | [Hazard]
A poison | [Description]
Grayanotoxin III (GTX-III) is a diterpene toxin that has been found in R. ponticum nectar, a component of mad honey.1 In vivo, GTX-III (0.1 and 0.25 mg/kg) induces salivation, emesis, and hind paw paralysis in mice.2 It is lethal to mice (LD50 = 0.84 mg/kg).WARNING This product is not for human or veterinary use. | [References]
[1] ARZUM BAHAR KURTOGLU Gulsun A E Recep Yavuz. Characterisation and fate of grayanatoxins in mad honey produced from Rhododendron ponticum nectar[J]. Food Chemistry, 2014, 161: Pages 47-52. DOI: 10.1016/j.foodchem.2014.03.127
[2] T. OHGAKI . Preventive action of quisqualic acid against grayanotoxin-induced suppression of locomotor activity in mice[J]. Neuropharmacology, 1988, 27 10: Pages 1045-1053. DOI: 10.1016/0028-3908(88)90066-4 |
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