| Identification | Back Directory | [Name]
N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]-benzamide monomethanesulfonate (9CI) | [CAS]
469861-49-2 | [Synonyms]
GW438014A
GW 438014A
GW 438014A;GW-438014A
GW438014A >=98% (HPLC)
N-(1-Phenethyl-1H-benzo[d]imidazol-2-yl)benzamide methanesulfonate
N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]-benzamide monomethanesulfonate (9CI) | [Molecular Formula]
C23H23N3O4S | [MOL File]
469861-49-2.mol | [Molecular Weight]
437.51 |
| Hazard Information | Back Directory | [Uses]
GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1]. | [in vivo]
GW438014A (10 mg/kg; i.p.; daily, for 7 d) inhibits spontaneous as well as overnight fasting-induced and NPY-induced feeding in rats and in food-deprived genetically obese ob/ob mice[1]. | Animal Model: | obese ob/ob mice[1] | | Dosage: | 10 mg/kg | | Administration: | intraperitoneal injection; daily, for 7 d | | Result: | Decreased the rate of weight gain in both lean and obese rats. |
| [References]
[1] Daniels AJ, et, al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54. DOI:10.1016/s0167-0115(02)00034-4 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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